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Which over the counter sleep aid works best? Sleep aids: The options Diphenhydramine (Benadryl, Aleve PM, others). Diphenhydramine is a sedating antihistamine. Doxylamine succinate (Unisom SleepTabs). Doxylamine is also a sedating antihistamine. Melatonin. The hormone melatonin helps control your natural sleep-wake cycle. Valerian.
Is Unisom safe for long term use? Is it safe to take Unisom or other over-the-counter sleeping pills long - term ? No. You can buy the drugs without a prescription, but they're not meant to be used for more than two weeks. That's because long - term use can lead to dependence, rebound insomnia, and delirium.
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